My first thought is that one story Spoony told about a D&D campaign set in Wonderland where quite literally everything was out to kill them and they were all high level encounters, one being a 20-level Monk. It was a meat-grinder, basically, though apparently his GM upped the levels to better match the characters. Most the encounters would be against Gargantuan or Colossal enemies, with the occasional Huge ones, and the rare Large and smaller ones. At least, that's probably how it would be look outside of safe settlements.