What one thing I would save if the Earth was about to be destroyed huh? Well, the Earth of course! Take that aliens!
...But to give a more serious answer xP if I'm choosing for myself, then I would save the electric guitar that was passed down from my granddad as that's my most priceless owned thing. But if I had to choose something for the whole Earth, then I'd like to save a mixtape with recordings of monologues and different types of music. Just a range of super important recordings onto it really, it would be the hypest humanity mixtape ever.